Cihlar, Toma: search on Z-Library

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1

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

Brown, Ariane J., Won, John J., Graham, Rachel L., Dinnon, Kenneth H., Sims, Amy C., Feng, Joy Y., Cihlar, Tomas, Denison, Mark R., Baric, Ralph S., Sheahan, Timothy P.

Journal:

Antiviral Research

Year:

2019

Language:

english

File:

PDF, 19.24 MB

english, 2019

2

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

de Wit, Emmie, Feldmann, Friederike, Cronin, Jacqueline, Jordan, Robert, Okumura, Atsushi, Thomas, Tina, Scott, Dana, Cihlar, Tomas, Feldmann, Heinz

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

Language:

english

File:

PDF, 1.21 MB

english, 2020

3

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

Lo, Michael K., Feldmann, Friederike, Gary, Joy M., Jordan, Robert, Bannister, Roy, Cronin, Jacqueline, Patel, Nishi R., Klena, John D., Nichol, Stuart T., Cihlar, Tomas, Zaki, Sherif R., Feldmann, He

Journal:

Science Translational Medicine

Year:

2019

Language:

english

File:

PDF, 1.27 MB

english, 2019

4

Blood biomarkers of expressed and inducible HIV-1

Cillo, Anthony R., Hong, Francis, Tsai, Angela, Irrinki, Alivelu, Kaur, Jasmine, Sloan, Derek D., Follen, Mattie, Geleziunas, Romas, Cihlar, Tomas, Win, Sandra S., Murry, Jeffrey P., Mellors, John W.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

5

Accelerating Drug Development: Antiviral Therapies for Emerging Viruses as a Model

Everts, Maaike, Cihlar, Tomas, Bostwick, J. Robert, Whitley, Richard J.

Journal:

Annual Review of Pharmacology

Year:

2017

Language:

english

File:

PDF, 591 KB

english, 2017

6

Toll-Like Receptor 7 Agonist GS-9620 Induces HIV Expression and HIV-Specific Immunity in Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy

Tsai, Angela, Irrinki, Alivelu, Kaur, Jasmine, Cihlar, Tomas, Kukolj, George, Sloan, Derek D., Murry, Jeffrey P., Silvestri, Guido

Journal:

Journal of Virology

Year:

2017

Language:

english

File:

PDF, 2.91 MB

english, 2017

7

Drug resistance assessment following administration of RSV fusion inhibitor presatovir to participants experimentally infected with respiratory syncytial virus

Stray, Kirsten, Perron, Michel, Porter, Danielle P, Anderson, Francisco, Lewis, Sandra A, Perry, Jason, Miller, Michael, Cihlar, Tomas, DeVincenzo, John, Chien, Jason W, Jordan, Robert

Journal:

The Journal of Infectious Diseases

Year:

2020

Language:

english

File:

PDF, 747 KB

english, 2020

8

Abyssomicin 2 Reactivates Latent HIV-1 by a PKC- and HDAC-Independent Mechanism

León, Brian, Navarro, Gabriel, Dickey, Bailey J., Stepan, George, Tsai, Angela, Jones, Gregg S., Morales, Monica E., Barnes, Tiffany, Ahmadyar, Shekeba, Tsiang, Manuel, Geleziunas, Romas, Cihlar, Toma

Journal:

Organic Letters

Year:

2015

Language:

english

File:

PDF, 690 KB

english, 2015

9

Human Respiratory Syncytial Virus Memphis 37 Grown in HEp-2 Cells Causes more Severe Disease in Lambs than Virus Grown in Vero Cells

Derscheid, Rachel, van Geelen, Albert, McGill, Jodi, Gallup, Jack, Cihlar, Tomas, Sacco, Randy, Ackermann, Mark

Journal:

Year:

2013

Language:

english

File:

PDF, 897 KB

english, 2013

10

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

Petr Jansa, Ondřej Baszczyňski, Martin Dračínský, Ivan Votruba, Zdeněk Zídek, Gina Bahador, George Stepan, Tomas Cihlar, Richard Mackman, Antonín Holý, Zlatko Janeba

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.61 MB

english, 2011

11

Cytomegalovirus Ventriculoencephalitis in a Bone Marrow Transplant Recipient Receiving Antiviral Maintenance: Clinical and Molecular Evidence of Drug Resistance

Seo, Susan K., Regan, Anne, Cihlar, Tomas, Lin, Deborah C., Boulad, Farid, George, Diane, Prasad, Vinod K., Kiehn, Timothy E., Polsky, Bruce

Journal:

Clinical Infectious Diseases

Year:

2001

Language:

english

File:

PDF, 71 KB

english, 2001

12

Tenofovir alafenamide (TAF) does not deplete mitochondrial DNA in human T-cell lines at intracellular concentrations exceeding clinically relevant drug exposures

Stray, Kirsten M., Park, Yeojin, Babusis, Darius, Callebaut, Christian, Cihlar, Tomas, Ray, Adrian S., Perron, Michel

Journal:

Antiviral Research

Year:

2017

Language:

english

File:

PDF, 942 KB

english, 2017

13

Current status and challenges of antiretroviral research and therapy

José A. Esté, Tomas Cihlar

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 265 KB

english, 2010

14

Human N6-Methyl-AMP/DAMP Aminohydrolase (Abacavir 5'-Monophosphate Deaminase) is Capable of Metabolizing N6-Substituted Purine Acyclic Nucleoside Phosphonates

Schinkmanová, Markéta, Votruba, Ivan, Shibata, Riri, Han, Bin, Liu, Xiaohong, Cihlar, Tomas, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

2008

Language:

english

File:

PDF, 312 KB

english, 2008

15

Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Anti-papillomavirus Agent GS-9191

Gabriel Birkus, Nilima Kutty, Christian Frey, Riri Shribata, Tsuifen Chou, Carston Wagner, Martin McDermott, Tomas Cihlar

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 75 KB

english, 2011

16

Biological Profiling of GS-9350, a Novel Pharmacoenhancer that Lacks Anti-HIV Activity and Exhibits Low Potential for Metabolic Adverse Effects In Vitro

Christian Callebaut, Luong Tsai, Kirsten Stray, Hongtao Liu, Lianhong Xu, Manoj Desai, Tomas Cihlar

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 70 KB

english, 2010

17

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides

Petr Nauš, Pavla Perlíková, Aurelie Bourderioux, Radek Pohl, Lenka Slavětínská, Ivan Votruba, Gina Bahador, Gabriel Birkuš, Tomáš Cihlář, Michal Hocek

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 919 KB

english, 2012

18

[Annual Reports in Medicinal Chemistry] Volume 35 || Chapter 16. Recent developments in antiretroviral therapies

Year:

2000

Language:

english

File:

PDF, 784 KB

english, 2000

19

TLR7 Agonist GS-9620 Is a Potent Inhibitor of Acute HIV-1 Infection in Human Peripheral Blood Mononuclear Cells

Bam, Rujuta A., Hansen, Derek, Irrinki, Alivelu, Mulato, Andrew, Jones, Gregg S., Hesselgesser, Joseph, Frey, Christian R., Cihlar, Tomas, Yant, Stephen R.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2016

Language:

english

File:

PDF, 1000 KB

english, 2016

20

Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor

Constantine G. Boojamra, Richard L. Mackman, David Y. Markevitch, Vidya Prasad, Adrian S. Ray, Janet Douglas, Deborah Grant, Choung U. Kim, Tomas Cihlar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 137 KB

english, 2008

21

Activation of GS-7340 and Other Tenofovir Phosphonoamidate Prodrugs by Human Proteases

Gabriel Birkus, Nilima Kutty, Gong-Xin He, Andrew Mulato, William Lee, Martin McDermott, Tomas Cihlar

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 58 KB

english, 2007

22

Discovery of GS-8374, a potent human immunodeficiency virus type 1 protease inhibitor with a superior resistance profile

He, Gong-Xing, Yang, Zheng-Yu, Williams, Matthew, Callebaut, Christian, Cihlar, Tomas, Murray, Bernard P., Yang, Chris, Mitchell, Michael L., Liu, Hongtao, Wang, Jianying, Arimilli, Murty, Eisenberg,

Journal:

Year:

2011

Language:

english

File:

PDF, 209 KB

english, 2011

23

Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148

Richard L. Mackman, Kuei-Ying Lin, Constantine G. Boojamra, Hon Hui, Janet Douglas, Deborah Grant, Oleg Petrakovsky, Vidya Prasad, Adrian S. Ray, Tomas Cihlar

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 132 KB

english, 2008

24

Topical Tenofovir, a Microbicide Effective against HIV, Inhibits Herpes Simplex Virus-2 Replication

Graciela Andrei, Andrea Lisco, Christophe Vanpouille, Andrea Introini, Emanuela Balestra, Joost van den Oord, Tomas Cihlar, Carlo-Federico Perno, Robert Snoeck, Leonid Margolis, Jan Balzarini

Journal:

Cell Host & Microbe

Year:

2011

Language:

english

File:

PDF, 1.10 MB

english, 2011

25

Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP (dAMP) kinase from L1210 cells

Aleš Merta, Ivan Votruba, Jindřich Jindřich, Antonín Holý, Tomás̆ Cihlář, Ivan Rosenberg, Miroslav Otmar, Tchaou Y. Herve

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.01 MB

english, 1992

26

Fluorescence-Based Assay for the Interaction of Small Molecules with the Human Renal Organic Anion Transporter 1

Tomas Cihlar, Edmund S. Ho

Journal:

Analytical Biochemistry

Year:

2000

Language:

english

File:

PDF, 91 KB

english, 2000

27

Novel targets for HIV therapy

Warner C. Greene, Zeger Debyser, Yasuhiro Ikeda, Eric O. Freed, Edward Stephens, Wes Yonemoto, Robert W. Buckheit, José A. Esté, Tomas Cihlar

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 1.70 MB

english, 2008

28

Expression of the Catalytic Subunit (UL54) and the Accessory Protein (UL44) of Human Cytomegalovirus DNA Polymerase in a Coupledin VitroTranscription/Translation System

Tomas Cihlar, Michael D. Fuller, Julie M. Cherrington

Journal:

Protein Expression and Purification

Year:

1997

Language:

english

File:

PDF, 312 KB

english, 1997

29

Human Respiratory Syncytial Virus Memphis 37 Causes Acute Respiratory Disease in Perinatal Lamb Lung

Derscheid, Rachel J., van Geelen, Albert, Gallup, Jack M., Kienzle, Thomas, Shelly, Daniel A., Cihlar, Tomas, King, Robert R., Ackermann, Mark R.

Journal:

BioResearch Open Access

Year:

2014

Language:

english

File:

PDF, 773 KB

english, 2014

30

Antiviral Efficacy of a Respiratory Syncytial Virus (RSV) Fusion Inhibitor in a Bovine Model of RSV Infection

Jordan, Robert, Shao, Matt, Mackman, Richard L., Perron, Michel, Cihlar, Tomas, Lewis, Sandy A., Eisenberg, Eugene J., Carey, Anne, Strickley, Robert G., Chien, Jason W., Anderson, Mark L., McEligot,

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 1.60 MB

english, 2015

31

Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors

Cihlar, Tomas, Ray, Adrian S., Laflamme, Genevieve, Vela, Jennifer E., Tong, Leah, Fuller, Michael D., Roy, Anupma, Rhodes, Gerald R.

Journal:

Antiviral Therapy

Year:

2007

Language:

english

File:

PDF, 276 KB

english, 2007

32

Impact of blood pressure levels within first 24 hours after mechanical thrombectomy on clinical outcome in acute ischemic stroke patients

Cernik, David, Sanak, Daniel, Divisova, Petra, Kocher, Martin, Cihlar, Filip, Zapletalova, Jana, Veverka, Tomas, Prcuchova, Andrea, Ospalik, Dusan, Cerna, Marie, Janousova, Petra, Kral, Michal, Dornak

Journal:

Journal of NeuroInterventional Surgery

Year:

2019

File:

PDF, 245 KB

2019

33

Low In Vitro Potential for Class-specific Toxicity of GS-9148, A Novel Nucleotide Reverse Transcriptase Inhibitor

Genevieve Laflamme, Constantin Boojamra, Lijun Zhang, Hon Hui, Robyn Fisher, Richard Mackman, Adrian Ray, Tomas Cihlar

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

34

Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors

Tomas Cihlar, Gabriel Birkus, Dale E Greenwalt, Michael J.M Hitchcock

Journal:

Antiviral Research

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

35

Mechanical Thrombectomy in Patients with Acute Ischemic Stroke on Anticoagulation Therapy

Černík, David, Šaňák, Daniel, Divišová, Petra, Köcher, Martin, Cihlář, Filip, Zapletalová, Jana, Veverka, Tomáš, Prcúchová, Andrea, Ospalík, Dušan, Černá, Marie, Janoušová, Petra, Král, Michal, Dorňák

Journal:

CardioVascular and Interventional Radiology

Year:

2018

Language:

english

File:

PDF, 385 KB

english, 2018

36

539. GS-CA2: A Novel, Potent, and Selective First-In-class Inhibitor of HIV-1 Capsid Function Displays Nonclinical Pharmacokinetics Supporting Long-Acting Potential in Humans

Zheng, Jim, Yant, Stephen R, Ahmadyar, Shekeba, Chan, Tiffany Y, Chiu, Anna, Cihlar, Tomas, Link, John O, Lu, Bing, Mwangi, Judy, Rowe, William, Schroeder, Scott D, Stepan, George J, Wang, Kelly Wei,

Journal:

Open Forum Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 877 KB

english, 2018

37

Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

Marcela Krecmerova, Antonin Holy, Graciela Andrei, Karel Pomeisl, Tomas Tichy, Genevieve Laflamme, Lieve Naesens, Tomas Cihlar, Johan Neyts, Erik De Clercq, Jan Balzarini, Robert Snoeck

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 105 KB

english, 2010

38

GS-8374, a Novel Phosphonate HIV Protease Inhibitor with Potent In Vitro Antiretroviral Activity, Low Metabolic Toxicity, and Favorable Resistance Profile

Christian Callebaut, Kirsten Stray, Luong Tsai, Lianhong Xu, Gong-Xin He, Andrew Mulato, Tina Priskich, Neil Parkin, William Lee, Tomas Cihlar

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

39

Inhibition of the human organic anion transporter 1 by the caffeine metabolite 1-methylxanthine

Jens Rengelshausen, Heike Lindenmaier, Tomas Cihlar, Ingeborg Walter-Sack, Walter Emil Haefeli, Johanna Weiss

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 363 KB

english, 2004

40

Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring

Tomas Cihlar, Gong-Xin He, Xiaohong Liu, James M. Chen, Marcos Hatada, Swami Swaminathan, Martin J. McDermott, Zheng-Yu Yang, Andrew S. Mulato, Xiaowu Chen, Stephanie A. Leavitt, Kirsten M. Stray, Wil

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 790 KB

english, 2006

41

Rapid In Vitro Evaluation of Antiretroviral Barrier to Resistance at Therapeutic Drug Levels

Mulato, Andrew, Hansen, Derek, Thielen, Alex, Porter, Danielle, Stepan, George, White, Kirsten, Daeumer, Martin, Cihlar, Tomas, Yant, Stephen R.

Journal:

AIDS Research and Human Retroviruses

Year:

2016

Language:

english

File:

PDF, 296 KB

english, 2016

42

A Point Mutation in the Human Cytomegalovirus DNA Polymerase Gene Selectedin Vitroby Cidofovir Confers a Slow Replication Phenotype in Cell Culture

Tomas Cihlar, Michael D. Fuller, Andrew S. Mulato, Julie M. Cherrington

Journal:

Year:

1998

Language:

english

File:

PDF, 1.33 MB

english, 1998

43

B106 New Nucleotides for the treatment of HIV infection

Rooney, James F, Miller, Michael, Cihlar, Tomas, Cheng, Andrew

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2013

Language:

english

File:

PDF, 6.37 MB

english, 2013

44

Current status and prospects of HIV treatment

Cihlar, Tomas, Fordyce, Marshall

Journal:

Current Opinion in Virology

Year:

2016

Language:

english

File:

PDF, 518 KB

english, 2016

45

Nucleotide HIV reverse transcriptase inhibitors: tenofovir and beyond

Journal:

Current Opinion in HIV and AIDS

Year:

2006

Language:

english

File:

PDF, 134 KB

english, 2006

46

Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity

Bam, Rujuta A, Yant, Stephen R, Cihlar, Tomas

Journal:

Antiviral Therapy

Year:

2014

Language:

english

File:

PDF, 206 KB

english, 2014

47

HUMAN RENAL ORGANIC ANION TRANSPORTER 1 (hOAT1) AND ITS ROLE IN THE NEPHROTOXICITY OF ANTIVIRAL NUCLEOTIDE ANALOGS

Cihlar, Tomas, Ho, Edmund S., Lin, Deborah C., Mulato, Andrew S.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2001

Language:

english

File:

PDF, 154 KB

english, 2001

48

Search for small molecule activators of latent HIV

Geleziunas, Romas, Stepan, George, Wei, George, Yu, Helen, Graupe, Michael, Pagratis, Nikos, Barnes, Tiffany, Cihlar, Tomas, Hesselgesser, Joe

Journal:

Year:

2012

Language:

english

File:

PDF, 72 KB

english, 2012

49

Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors

Bam, Rujuta A, Birkus, Gabriel, Babusis, Darius, Cihlar, Tomas, Yant, Stephen R

Journal:

Antiviral Therapy

Year:

2014

Language:

english

File:

PDF, 313 KB

english, 2014

50

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

Tomas Cihlar, Adrian S. Ray

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 948 KB

english, 2010

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